Regatta Wines has taken over the former Henley Model Miniatures shop in Reading Road.
It is owned by Paramjit Kalher and will be managed by his son, Satnam.
Mr Kalher snr and his brother have run about 13 off-licences in Slough, and Greenford over the past 35 years. Mr Kulher jnr, 29, from Burnham, said he was looking forward to running the business using his family?s experience and guidance.
?I have wanted to be my own boss,? he said. ?We were looking for somewhere round this area and this was a closed shop so it seemed like a good opportunity as it?s a nice area.?
The shop stocks a wide selection of alcoholic and soft drinks as well as cigarettes and sweets.