Oxfordshire County Council has issued a notice for the temporary closure of the north-west-bound carriageway of the A4130 between the junction with the B480 at Lower Assendon and the crossroad near Bix Manor.
The road will be closed to allow repairs of the northern stretch of the carriageway, which has been coned off for months due to severe erosion of the verge side of the carriageway.
This is in addition to more comprehensive work planned for next spring, when both carriageways will be resurfaced and roadside drainage will be improved.
Road closure and diversion signs will be placed in Henley with the aim of diverting through traffic along Reading Road and in Caversham to divert traffic along the A4074.
There are also diversions available via Old Bix Road, Broadplat and the B480, although there is a seven-and-a-half tonnes weight limit on the latter.
The county council also plans to cone the south-east-bound carriageway that travels downhill to make it one lane and reduce traffic speed.
There will also be temporary traffic lights at the Lower Assendon junction between the A4130 and B480 as a safety measure because of the expected increase in traffic in that area.
Discussions are taking place to try find a suitable temporary bus route to allow local services to continue during the works.
Councillor David Nimmo Smith, who represents the county council in the Henley ward, has asked Insp Mark Harling, head of Henley Police, for officers to begin patrols on the B480 to discourage lorries above the weight limit from using the road.